XGef mediates early CPEB phosphorylation during Xenopus oocyte meiotic maturation.

@article{Martnez2005XGefME,
  title={XGef mediates early CPEB phosphorylation during Xenopus oocyte meiotic maturation.},
  author={Susana E Mart{\'i}nez and Lei Yuan and Charlemagne T Lacza and Heather Ransom and Gwendolyn M. Mahon and Ian Whitehead and Laura E. Hake},
  journal={Molecular biology of the cell},
  year={2005},
  volume={16 3},
  pages={
          1152-64
        }
}
Polyadenylation-induced translation is an important regulatory mechanism during metazoan development. During Xenopus oocyte meiotic progression, polyadenylation-induced translation is regulated by CPEB, which is activated by phosphorylation. XGef, a guanine exchange factor, is a CPEB-interacting protein involved in the early steps of progesterone-stimulated oocyte maturation. We find that XGef influences early oocyte maturation by directly influencing CPEB function. XGef and CPEB interact… CONTINUE READING
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