XCtBP is a XTcf-3 co-repressor with roles throughout Xenopus development.

  title={XCtBP is a XTcf-3 co-repressor with roles throughout Xenopus development.},
  author={Mark Brannon and Jeffrey D. Brown and Rebecca Bates and David Kimelman and Randall T. Moon},
  volume={126 14},
XTcf-3 is an HMG box transcription factor that mediates Xenopus dorsal-ventral axis formation. As a Wnt pathway effector, XTcf-3 interacts with beta-catenin and activates the expression of the dorsal organizing gene siamois, while in the absence of beta-catenin, XTcf-3 functions as a transcriptional repressor. We show that XTcf-3 contains amino- and carboxy-terminal repressor domains and have identified a Xenopus member of the C-terminal Binding Protein family of transcriptional co-repressors… CONTINUE READING
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