XCL1 and XCR1 in the immune system.

  title={XCL1 and XCR1 in the immune system.},
  author={Yu Lei and Yousuke Takahama},
  journal={Microbes and infection},
  volume={14 3},
XCL1, a C class chemokine also known as lymphotactin, is produced by T, NK, and NKT cells during infectious and inflammatory responses, whereas XCR1, the receptor of XCL1, is expressed by a dendritic cell subpopulation. The XCL1-XCR1 axis plays an important role in dendritic-cell-mediated cytotoxic immune response. It has been also shown that XCL1 and XCR1 are constitutively expressed in the thymus and regulate the thymic establishment of self-tolerance and the generation of regulatory T cells… CONTINUE READING
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