XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation.

@article{Shaffer2004XBP1DO,
  title={XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation.},
  author={A. Shaffer and Miriam Shapiro-Shelef and N. Iwakoshi and Ann-Hwee Lee and Shu-Bing Qian and Hong Zhao and Xin Yu and Liming Yang and B. Tan and A. Rosenwald and E. Hurt and E. Petroulakis and N. Sonenberg and J. Yewdell and K. Calame and L. Glimcher and L. Staudt},
  journal={Immunity},
  year={2004},
  volume={21 1},
  pages={
          81-93
        }
}
The differentiation of B cells into immunoglobulin-secreting plasma cells is controlled by two transcription factors, Blimp-1 and XBP1. By gene expression profiling, we defined a set of genes whose induction during mouse plasmacytic differentiation is dependent on Blimp-1 and/or XBP1. Blimp-1-deficient B cells failed to upregulate most plasma cell-specific genes, including xbp1. Differentiating xbp1-deficient B cells induced Blimp-1 normally but failed to upregulate genes encoding many… Expand
XBP-1 specifically promotes IgM synthesis and secretion, but is dispensable for degradation of glycoproteins in primary B cells
Initiation of plasma-cell differentiation is independent of the transcription factor Blimp-1.
Vav Proteins Regulate the Plasma Cell Program and Secretory Ig Production1
Expression pattern of XBP1(S) in human B-cell lymphomas
Different Kinetics of Blimp-1 Induction in B Cell Subsets Revealed by Reporter Gene1
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  • Neal N. Iwakoshi, Ann-Hwee Lee, Laurie H. Glimcher
  • Biology, Medicine
  • Immunological reviews
  • 2003
Membrane biogenesis during B cell differentiation: most endoplasmic reticulum proteins are expressed coordinately
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response
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