XBP-1 couples endoplasmic reticulum stress to augmented IFN-beta induction via a cis-acting enhancer in macrophages.

@article{Zeng2010XBP1CE,
  title={XBP-1 couples endoplasmic reticulum stress to augmented IFN-beta induction via a cis-acting enhancer in macrophages.},
  author={Ling Ge Zeng and Yiping Liu and Haibo Sha and Hui Chen and Ling Qi and Judith A. Smith},
  journal={Journal of immunology},
  year={2010},
  volume={185 4},
  pages={2324-30}
}
Perturbation of the endoplasmic reticulum (ER) results in a conserved stress response called the unfolded protein response (UPR). Macrophages undergoing a UPR respond to LPS with log-fold increased production of IFN-beta, a cytokine with diverse roles in innate and adaptive immunity. In this study, we found that thapsigargin-induced ER stress augmented recruitment of IFN regulatory factor-3, CREB binding protein/p300, and transcriptional machinery to the murine ifnb1 promoter during LPS… CONTINUE READING

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