X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

@article{Nury2011XraySO,
  title={X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel},
  author={Hugues Nury and Catherine Van Renterghem and Yun Weng and Alphonso Tran and Marc Baaden and Virginie Dufresne and Jean-Pierre Changeux and James M. Sonner and Marc Delarue and Pierre-Jean Corringer},
  journal={Nature},
  year={2011},
  volume={469},
  pages={428-431}
}
General anaesthetics have enjoyed long and widespread use but their molecular mechanism of action remains poorly understood. There is good evidence that their principal targets are pentameric ligand-gated ion channels (pLGICs) such as inhibitory GABAA (γ-aminobutyric acid) receptors and excitatory nicotinic acetylcholine receptors, which are respectively… CONTINUE READING