X-ray structure of motor and neck domains from rat brain kinesin.

  title={X-ray structure of motor and neck domains from rat brain kinesin.},
  author={Suellen Sack and Jens M{\"u}ller and Alexander Marx and Marion Thorm{\"a}hlen and E M Mandelkow and Scott T Brady},
  volume={36 51},
We have determined the X-ray structure of rat kinesin head and neck domains. The folding of the core motor domain resembles that of human kinesin reported recently [Kull, F. J., et al. (1996) Nature 380, 550-554]. Novel features of the structure include the N-terminal region, folded as a beta-strand, and the C-terminal transition from the motor to the rod domain, folded as two beta-strands plus an alpha-helix. This helix is the beginning of kinesin's neck responsible for dimerization of the… CONTINUE READING

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