X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex
@article{Griffith1995XraySO, title={X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex}, author={J. Griffith and J. Kim and E. Kim and M. Sintchak and J. Thomson and M. Fitzgibbon and M. Fleming and P. Caron and K. Hsiao and M. Navia}, journal={Cell}, year={1995}, volume={82}, pages={507-522} }
The X-ray structure of the ternary complex of a calcineurin A fragment, calcineurin B, FKBP12, and the immunosuppressant drug FK506 (also known as tacrolimus) has been determined at 2.5 A resolution, providing a description of how FK506 functions at the atomic level. In the structure, the FKBP12-FK506 binary complex does not contact the phosphatase active site on calcineurin A that is more than 10 A removed. Instead, FKBP12-FK506 is so positioned that it can inhibit the dephosphorylation of its… Expand
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