X-ray structure of a voltage-dependent K+ channel

@article{Jiang2003XraySO,
  title={X-ray structure of a voltage-dependent K+ channel},
  author={Y. Jiang and A. Lee and J. Chen and V. Ruta and M. Cad{\`e}ne and Brian T. Chait and R. MacKinnon},
  journal={Nature},
  year={2003},
  volume={423},
  pages={33-41}
}
  • Y. Jiang, A. Lee, +4 authors R. MacKinnon
  • Published 2003
  • Chemistry, Medicine
  • Nature
  • Voltage-dependent K+ channels are members of the family of voltage-dependent cation (K+, Na+ and Ca2+) channels that open and allow ion conduction in response to changes in cell membrane voltage. This form of gating underlies the generation of nerve and muscle action potentials, among other processes. Here we present the structure of KvAP, a voltage-dependent K+ channel from Aeropyrum pernix. We have determined a crystal structure of the full-length channel at a resolution of 3.2 Å, and of the… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 47 REFERENCES
    The voltage sensor in voltage-dependent ion channels.
    • 760
    • PDF
    Ion conduction pore is conserved among potassium channels
    • 300
    • PDF