X-ray structure of a minor group human rhinovirus bound to a fragment of its cellular receptor protein

@article{Verdaguer2004XraySO,
  title={X-ray structure of a minor group human rhinovirus bound to a fragment of its cellular receptor protein},
  author={N{\'u}ria Verdaguer and Ignacio Fita and Manuela Reithmayer and Rosita Moser and Dieter Blaas},
  journal={Nature Structural &Molecular Biology},
  year={2004},
  volume={11},
  pages={429-434}
}
Although many viral receptors have been identified, the ways in which they interact with their cognate viruses are not understood at the molecular level. We have determined the X-ray structure of a complex between calcium-containing modules of the very low-density lipoprotein receptor and the minor group human rhinovirus HRV2. The receptor binds close to the icosahedral five-fold vertex, with only one module per virus protomer. The binding face of this module is defined by acidic calcium… CONTINUE READING

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