X-ray structure of RLI, an essential twin cassette ABC ATPase involved in ribosome biogenesis and HIV capsid assembly.

@article{Karcher2005XraySO,
  title={X-ray structure of RLI, an essential twin cassette ABC ATPase involved in ribosome biogenesis and HIV capsid assembly.},
  author={Annette Karcher and Katharina Buettner and Birgit M{\"a}rtens and R. Jansen and Charlotte L{\"a}ssig},
  journal={Structure},
  year={2005},
  volume={13 4},
  pages={
          649-59
        }
}
The ABC ATPase RNase-L inhibitor (RLI) emerges as a key enzyme in ribosome biogenesis, formation of translation preinitiation complexes, and assembly of HIV capsids. To help reveal the structural mechanism of RLI, we determined the Mg2+-ADP bound crystal structure of the twin cassette ATPase of P. furiosus RLI at 1.9 A resolution and analyzed functional motifs in yeast in vivo. RLI shows similarities but also differences to known ABC enzyme structures. Twin nucleotide binding domains (NBD1 and… CONTINUE READING
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