X-ray structure of EmrE supports dual topology model.

@article{Chen2007XraySO,
  title={X-ray structure of EmrE supports dual topology model.},
  author={Yen-Ju Chen and Owen Pornillos and Samantha S Lieu and Che Ma and Andy P. Chen and Geoffrey Chang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 48},
  pages={18999-9004}
}
EmrE, a multidrug transporter from Escherichia coli, functions as a homodimer of a small four-transmembrane protein. The membrane insertion topology of the two monomers is controversial. Although the EmrE protein was reported to have a unique orientation in the membrane, models based on electron microscopy and now defunct x-ray structures, as well as recent… CONTINUE READING