X-ray structure and mechanism of RNA polymerase II stalled at an antineoplastic monofunctional platinum-DNA adduct.

Abstract

DNA is a major target of anticancer drugs. The resulting adducts interfere with key cellular processes, such as transcription, to trigger downstream events responsible for drug activity. cis-Diammine(pyridine)chloroplatinum(II), cDPCP or pyriplatin, is a monofunctional platinum(II) analogue of the widely used anticancer drug cisplatin having significant… (More)
DOI: 10.1073/pnas.1002565107

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@article{Wang2010XraySA, title={X-ray structure and mechanism of RNA polymerase II stalled at an antineoplastic monofunctional platinum-DNA adduct.}, author={Dong Wang and Guangyu Zhu and Xuhui Huang and Stephen J Lippard}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2010}, volume={107 21}, pages={9584-9} }