X-ray repair cross-complementing gene I protein plays an important role in camptothecin resistance.

@article{Park2002XrayRC,
  title={X-ray repair cross-complementing gene I protein plays an important role in camptothecin resistance.},
  author={Shin-Young Park and Wing Lam and Yung-chi Cheng},
  journal={Cancer research},
  year={2002},
  volume={62 2},
  pages={
          459-65
        }
}
X-ray repair cross-complementing gene I protein (XRCC1) in complex with DNA polymerase beta, DNA ligase III, and poly(ADP-ribose) polymerase is important in the base excision repair process. Previously, we isolated camptothecin (CPT)-resistant cell lines (KB100 and KB300) from the human epidermoid carcinoma cell line KB by exposure to CPT. From these CPT-resistant cell lines, their revertants (KB100(rev) and KB300(rev)), which lost most of their CPT-resistant phenotype during passage in the… CONTINUE READING

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