X-ray-induced telomeric instability in Atm-deficient mouse cells.

  title={X-ray-induced telomeric instability in Atm-deficient mouse cells.},
  author={Barkhaa Undarmaa and Seiji Kodama and Keiji Suzuki and Ohtsura Niwa and Masami Watanabe},
  journal={Biochemical and biophysical research communications},
  volume={315 1},
The gene responsible for ataxia telangiectasia (AT) encodes ATM protein, which plays a major role in the network of a signal transduction initiated by double strand DNA breaks. To determine how radiation-induced genomic instability is modulated by the dysfunction of ATM protein, we examined radiation-induced delayed chromosomal instability in individual cell lines established from wild-type Atm(+/+), heterozygote Atm(+/-), and knock-out Atm(-/-) mouse embryos. The results indicate that Atm… CONTINUE READING


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