X-ray crystallography in drug discovery.

@article{Carvalho2009XrayCI,
  title={X-ray crystallography in drug discovery.},
  author={Ana Lu{\'i}sa Carvalho and Jos{\'e} Trinc{\~a}o and Maria Jo{\~a}o Rom{\~a}o},
  journal={Methods in molecular biology},
  year={2009},
  volume={572},
  pages={31-56}
}
Macromolecular X-ray crystallography is an important and powerful technique in drug discovery, used by pharmaceutical companies in the discovery process of new medicines. The detailed analysis of crystal structures of protein-ligand complexes allows the study of the specific interactions of a particular drug with its protein target at the atomic level. It… CONTINUE READING