X-ray crystallographic studies of CDK2, a basis for cyclin-dependent kinase inhibitor design in anti-cancer drug research.

@article{Furet2003XrayCS,
  title={X-ray crystallographic studies of CDK2, a basis for cyclin-dependent kinase inhibitor design in anti-cancer drug research.},
  author={Pascal Furet},
  journal={Current medicinal chemistry. Anti-cancer agents},
  year={2003},
  volume={3 1},
  pages={15-23}
}
  • Pascal Furet
  • Published 2003 in Current medicinal chemistry. Anti-cancer agents
Inhibition of cyclin-dependent kinases is a theme of major interest in current anti-cancer agents research. Different classes of chemical inhibitors of these enzymes have been identified during the past decade and the structural basis of inhibition has been elucidated by X-ray crystallography studies of one member of the family, CDK2. In this article, we review the structural biology work that has led to a precise knowledge of the interactions between CDK2 and small organic molecules binding to… CONTINUE READING