X-ray crystal structure of the rotavirus inner capsid particle at 3.8 A resolution.

  title={X-ray crystal structure of the rotavirus inner capsid particle at 3.8 A resolution.},
  author={Brian McClain and Ethan C. Settembre and Brenda R. S. Temple and A. Richard Bellamy and Stephen C Harrison},
  journal={Journal of molecular biology},
  volume={397 2},
The rotavirus inner capsid particle, known as the "double-layered particle" (DLP), is the "payload" delivered into a cell in the process of viral infection. Its inner and outer protein layers, composed of viral protein (VP) 2 and VP6, respectively, package the 11 segments of the double-stranded RNA (dsRNA) of the viral genome, as well as about the same number of polymerase molecules (VP1) and capping-enzyme molecules (VP3). We have determined the crystal structure of the bovine rotavirus DLP… CONTINUE READING


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Publications referenced by this paper.
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