X-ray crystal structure of the DNA-binding domain of response regulator WalR essential to the cell viability of staphylococcus aureus and interaction with target DNA.

@article{Doi2010XrayCS,
  title={X-ray crystal structure of the DNA-binding domain of response regulator WalR essential to the cell viability of staphylococcus aureus and interaction with target DNA.},
  author={Akihiro Doi and Toshihide Okajima and Yasuhiro Gotoh and Katsuyuki Tanizawa and Ryutaro Utsumi},
  journal={Bioscience, biotechnology, and biochemistry},
  year={2010},
  volume={74 9},
  pages={
          1901-7
        }
}
A bacterial two-component signal transduction system, WalK/WalR, is essential to the cell viability of Gram-positive bacteria and is therefore a potential target for the development of a new class of antibiotics. We have solved the X-ray crystal structure of the DNA-binding domain of the response regulator WalR (WalRc) from a Gram-positive pathogen Staphylococcus aureus, currently causing serious problems in public health through the acquisition of multi-drug resistance. The structure contains… CONTINUE READING
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