X-ray crystal structure of proto-oncogene product c-Rel bound to the CD28 response element of IL-2.

@article{Huang2001XrayCS,
  title={X-ray crystal structure of proto-oncogene product c-Rel bound to the CD28 response element of IL-2.},
  author={D B Huang and Yelin Chen and M Ruetsche and Christopher B. Phelps and Gourisankar Ghosh},
  journal={Structure},
  year={2001},
  volume={9 8},
  pages={669-78}
}
BACKGROUND The proto-oncogene product c-Rel is a Rel/NF-kappaB family transcription factor that plays a critical role in lymphoid cell development and mediates CD28-induced expression of interleukin 2 (IL-2). The CD28 response element (CD28RE) in the IL-2 enhancer is nonameric and similar to the kappaB DNA target sites recognized by p65 homodimers. RESULTS We have determined and refined the X-ray crystal structure of the c-Rel homodimer complexed to the CD28RE DNA site, 5'-AGAAATTCC-3', to 2… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

Similar Papers

Loading similar papers…