X-ray analysis of metal-substituted human carbonic anhydrase II derivatives.

@article{Hkansson1994XrayAO,
  title={X-ray analysis of metal-substituted human carbonic anhydrase II derivatives.},
  author={Katarina H{\aa}kansson and Anita Wehnert and Anders Liljas},
  journal={Acta crystallographica. Section D, Biological crystallography},
  year={1994},
  volume={50 Pt 1},
  pages={93-100}
}
Metal-substituted crystals of human carbonic anhydrase II belonging to space group P2(1) with cell dimensions a = 42.7, b = 41.7, c = 73.0 A and beta = 104.6 degrees were analyzed crystallographically. The resolution limit ranged from 1.82 to 1.92 A with high completeness (86.2-90.7%). Cobalt(II)-substituted carbonic anhydrase has a tetrahedral coordination around the metal both at pH 6 and pH 7.8, similar to the native zinc enzyme. In contrast, the catalytically inactive copper(II), nickel(II… CONTINUE READING

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