X-linked situs abnormalities result from mutations in ZIC3

@article{Gebbia1997XlinkedSA,
  title={X-linked situs abnormalities result from mutations in ZIC3},
  author={Marinella Gebbia and Giovanni Battista Ferrero and Giuseppe Pilia and Maria Teresa Bassi and Arthur S. Aylsworth and Miranda Penman-Splitt and Lynne M. Bird and J. Stephen Bamforth and John Burn and David Schlessinger and David L. Nelson and Brett Casey},
  journal={Nature Genetics},
  year={1997},
  volume={17},
  pages={305-308}
}
Vertebrates position unpaired organs of the chest and abdomen asymmetrically along the left–right (LR) body axis. Each structure comes to lie non-randomly with respect to the midline in an overall position designated situs solitus, exemplified in humans by placement of the heart, stomach and spleen consistently to the left. Aberrant LR axis development can lead to randomization of individual organ position (situs ambiguus) or to mirror-image reversal of all lateralized structures (situs in… 
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Members of the transforming growth factor (TGF)-beta family of cell-signaling molecules have been implicated recently in mammalian left-right (LR) axis development, the process by which vertebrates
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