X linked neonatal centronuclear/myotubular myopathy: evidence for linkage to Xq28 DNA marker loci.

@article{Thomas1990XLN,
  title={X linked neonatal centronuclear/myotubular myopathy: evidence for linkage to Xq28 DNA marker loci.},
  author={Nicholas S. T. Thomas and Hywel Williams and G. P. Cole and K. Roberts and Angus Clarke and Sabina Liechti-Gallati and Suzanne Braga and Alexandra Lehmkuhl Gerber and Christian Meier and H. S. Moser},
  journal={Journal of medical genetics},
  year={1990},
  volume={27 5},
  pages={284-7}
}
We have studied the inheritance of several polymorphic Xq27/28 DNA marker loci in two three generation families with the X linked neonatal lethal form of centronuclear/myotubular myopathy (XL MTM). We found complete linkage of XLMTM to all four informative Xq28 markers analysed, with GCP/RCP (Z = 3.876, theta = 0.00), with DXS15 (Z = 3.737, theta = 0.00), with DXS52 (Z = 2.709, theta = 0.00), and with F8C (Z = 1.020, theta = 0.00). In the absence of any observable recombination, we are unable… CONTINUE READING