X-linked midline defects.

  title={X-linked midline defects.},
  author={Helga V. Toriello and James V. Higgins},
  journal={American journal of medical genetics},
  volume={21 1},
Opitz and Gilbert [Am J Med Genet 12:443-455, 1982] have postulated that the midline may be a kind of developmental field. Although developmental field defects (primary malformations) usually occur sporadically, in some instances they can be caused by a single gene mutation. We report on a family in which the occurrence of midline defects was consistent… CONTINUE READING