X-linked inhibitor of apoptosis protein (XIAP) mediates cancer cell motility via Rho GDP dissociation inhibitor (RhoGDI)-dependent regulation of the cytoskeleton.

@article{Liu2011XlinkedIO,
  title={X-linked inhibitor of apoptosis protein (XIAP) mediates cancer cell motility via Rho GDP dissociation inhibitor (RhoGDI)-dependent regulation of the cytoskeleton.},
  author={Jinyi Liu and Dongyun Zhang and Wenjing Luo and Yonghui Yu and Jianxiu Yu and Jingxia Li and Xinhai Zhang and Baolin Zhang and Jing-yuan Chen and Xue-Ru Wu and Germ{\'a}n Rosas-Acosta and Chuanshu Huang},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 18},
  pages={15630-40}
}
X-linked inhibitor of apoptosis protein (XIAP) overexpression has been found to be associated with malignant cancer progression and aggression in individuals with many types of cancers. However, the molecular basis of XIAP in the regulation of cancer cell biological behavior remains largely unknown. In this study, we found that a deficiency of XIAP expression in human cancer cells by either knock-out or knockdown leads to a marked reduction in β-actin polymerization and cytoskeleton formation… CONTINUE READING

From This Paper

Topics from this paper.
35 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

Similar Papers

Loading similar papers…