X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility

@article{Dogan2008XlinkedAC,
  title={X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility},
  author={Taner Dogan and Gregory S. Harms and Mirko Hekman and Christiaan Karreman and Tripat Kaur Oberoi and Emad S Alnemri and Ulf R{\"u}diger Rapp and Krishnaraj Rajalingam},
  journal={Nature Cell Biology},
  year={2008},
  volume={10},
  pages={1447-1455}
}
Inhibitor of apoptosis proteins (IAP) are evolutionarily conserved anti-apoptotic regulators. C-RAF protein kinase is a direct RAS effector protein, which initiates the classical mitogen-activated protein kinase (MAPK) cascade. This signalling cascade mediates diverse biological functions, such as cell growth, proliferation, migration, differentiation and survival. Here we demonstrate that XIAP and c-IAPs bind directly to C-RAF kinase and that siRNA-mediated silencing of XIAP and c-IAPs leads… 
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TLDR
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TLDR
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X-linked Inhibitor of Apoptosis Protein negatively regulates neuronal differentiation through interaction with cRAF and Trk
TLDR
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X-linked Inhibitor of Apoptosis Protein (XIAP) Mediates Cancer Cell Motility via Rho GDP Dissociation Inhibitor (RhoGDI)-dependent Regulation of the Cytoskeleton*
TLDR
A deficiency of XIAP expression in human cancer cells by either knock-out or knockdown leads to a marked reduction in β-actin polymerization and cytoskeleton formation, which provides novel insights into the molecular mechanisms by which XIAP regulates cancer invasion.
The ubiquitin ligase HERC1 regulates cell migration via RAF-dependent regulation of MKK3/p38 signaling
TLDR
It is shown that the ubiquitin ligase HERC1 regulates the p38 signaling pathway, and that this regulation is mediated by the MAPK kinase MKK3, and a crosstalk between RAF/MKK3/p38 signaling pathways during cell migration is demonstrated.
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TLDR
It is shown that the N-terminus, LisH/CTLH and CRA domains of RanBPM are required for downregulation of c-Raf and that RanB PM interacts directly with c- Raf through its CRA domain, and that MAEA, another CTLH complex member, associates with c -Raf.
Ubiquitin-dependent regulation of Cdc42 by XIAP
TLDR
It is demonstrated that the highly conserved, RING domain containing E3 ubiquitin ligase XIAP controls the protein stability of Cdc42, a well-studied member of the family that controls filopodia formation and cell migration.
Role for X-linked Inhibitor of Apoptosis Protein Upstream of Mitochondrial Permeabilization*
TLDR
It is shown that in response to loss of survival signals provided by cell adhesion, endogenous XIAP translocates from the cytosol into a mitochondrial 400-kDa complex and that this occurs very early in the apoptosis process.
IAP Proteins and Their Therapeutic Potential
TLDR
IAP antagonists have successfully passed initial safety scrutiny in clinical trials and are about to enter a critical phase in their development in which their antitumor efficacy will be tested in the hopes of providing novel treatments for cancer patients.
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