X-inactivation reveals epigenetic anomalies in most hESC but identifies sublines that initiate as expected.

@article{Hall2008XinactivationRE,
  title={X-inactivation reveals epigenetic anomalies in most hESC but identifies sublines that initiate as expected.},
  author={Lisa L. Hall and Meg Byron and John L Butler and Klaus A. Becker and Angel M. Nelson and Michal Amit and Joseph Itskovitz-Eldor and Janet R. Stein and Gary Stein and Carol Ware and J B Lawrence},
  journal={Journal of cellular physiology},
  year={2008},
  volume={216 2},
  pages={445-52}
}
The clinical and research value of human embryonic stem cells (hESC) depends upon maintaining their epigenetically naïve, fully undifferentiated state. Inactivation of one X chromosome in each cell of mammalian female embryos is a paradigm for one of the earliest steps in cell specialization through formation of facultative heterochromatin. Mouse ES cells are derived from the inner cell mass (ICM) of blastocyst stage embryos prior to X-inactivation, and cultured murine ES cells initiate this… CONTINUE READING
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Mouse ES cells are derived from the inner cell mass ( ICM ) of blastocyst stage embryos prior to X - inactivation , and cultured murine ES cells initiate this process only upon differentiation .
Mouse ES cells are derived from the inner cell mass ( ICM ) of blastocyst stage embryos prior to X - inactivation , and cultured murine ES cells initiate this process only upon differentiation .
The many epigenetic anomalies seen indicate that maintenance of fully unspecialized cells , which have not formed Xi facultative heterochromatin , is a delicate epigenetic balance difficult to maintain in culture .
The many epigenetic anomalies seen indicate that maintenance of fully unspecialized cells , which have not formed Xi facultative heterochromatin , is a delicate epigenetic balance difficult to maintain in culture .
Mouse ES cells are derived from the inner cell mass ( ICM ) of blastocyst stage embryos prior to X - inactivation , and cultured murine ES cells initiate this process only upon differentiation .
Mouse ES cells are derived from the inner cell mass ( ICM ) of blastocyst stage embryos prior to X - inactivation , and cultured murine ES cells initiate this process only upon differentiation .
Inner cell massAnatomic structure is physical part ofBlastocyst structure
Mouse ES cells are derived from the inner cell mass ( ICM ) of blastocyst stage embryos prior to X - inactivation , and cultured murine ES cells initiate this process only upon differentiation .
The many epigenetic anomalies seen indicate that maintenance of fully unspecialized cells , which have not formed Xi facultative heterochromatin , is a delicate epigenetic balance difficult to maintain in culture .
The many epigenetic anomalies seen indicate that maintenance of fully unspecialized cells , which have not formed Xi facultative heterochromatin , is a delicate epigenetic balance difficult to maintain in culture .
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