X-domain of peptide synthetases recruits oxygenases crucial for glycopeptide biosynthesis

@article{Haslinger2015XdomainOP,
  title={X-domain of peptide synthetases recruits oxygenases crucial for glycopeptide biosynthesis},
  author={Kristina Haslinger and Madeleine Peschke and Clara Brieke and Eglė Maximowitsch and Max J. Cryle},
  journal={Nature},
  year={2015},
  volume={521},
  pages={105-109}
}
Non-ribosomal peptide synthetase (NRPS) mega-enzyme complexes are modular assembly lines that are involved in the biosynthesis of numerous peptide metabolites independently of the ribosome. The multiple interactions between catalytic domains within the NRPS machinery are further complemented by additional interactions with external enzymes, particularly focused on the final peptide maturation process. An important class of NRPS metabolites that require extensive external modification of the… 

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