X-chromosome linked inhibitor of apoptosis protein inhibits muscle proteolysis in insulin-deficient mice

@article{Wang2007XchromosomeLI,
  title={X-chromosome linked inhibitor of apoptosis protein inhibits muscle proteolysis in insulin-deficient mice},
  author={Xiaonan H Wang and Junping Hu and Jing Du and Janet D Klein},
  journal={Gene Therapy},
  year={2007},
  volume={14},
  pages={711-720}
}
Loss of muscle protein is a serious complication of catabolic diseases and contributes substantially to patients' morbidity and mortality. This muscle loss is mediated largely by the activation of the ubiquitin–proteasome system; however, caspase-3 catalyzes an initial step in this process by cleaving actomyosin into small protein fragments that are rapidly degraded by the proteasome-dependent proteolytic pathway. We hypothesized that X-chromosome linked inhibitor of apoptosis protein (XIAP… CONTINUE READING
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