X-chromosome inactivation: molecular mechanisms from the human perspective

  title={X-chromosome inactivation: molecular mechanisms from the human perspective},
  author={Christine Yang and Andrew G. Chapman and Angela D. Kelsey and Jakub Minks and Allison M. Cotton and C J Brown},
  journal={Human Genetics},
X-chromosome inactivation is an epigenetic process whereby one X chromosome is silenced in mammalian female cells. Since it was first proposed by Lyon in 1961, mouse models have been valuable tools to uncover the molecular mechanisms underlying X inactivation. However, there are also inherent differences between mouse and human X inactivation, ranging from sequence content of the X inactivation center to the phenotypic outcomes of X-chromosome abnormalities. X-linked gene dosage in males… CONTINUE READING