X chromosome gene methylation in peripheral lymphocytes from monozygotic twins discordant for scleroderma.

@article{Selmi2012XCG,
  title={X chromosome gene methylation in peripheral lymphocytes from monozygotic twins discordant for scleroderma.},
  author={Carlo Selmi and Carol Feghali-Bostwick and Ana Lleo and Simone A. Lombardi and Maria de Santis and Francesca Cavaciocchi and Luca Zammataro and Michelle M Mitchell and Janine M LaSalle and Thomas A Jr Medsger and M Eric Gershwin},
  journal={Clinical and experimental immunology},
  year={2012},
  volume={169 3},
  pages={253-62}
}
Scleroderma (SSc) is a rare connective tissue disease characterized by fibrosis, microvasculopathy and autoimmune features. The role of genetics is limited in SSc, as suggested by similar concordance rates in monozygotic and dizygotic twin pairs, while environmental factors may act through epigenetic changes, as demonstrated for specific genes. Further, sex chromosome changes have been reported in SSc and may explain the female preponderance. In the present study we compared the methylation… CONTINUE READING