X chromosome evidence for ancient human histories.

@article{Harris1999XCE,
  title={X chromosome evidence for ancient human histories.},
  author={Eugene E Harris and Jody Hey},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 6},
  pages={
          3320-4
        }
}
  • E. Harris, J. Hey
  • Published 1999
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
Diverse African and non-African samples of the X-linked PDHA1 (pyruvate dehydrogenase E1 alpha subunit) locus revealed a fixed DNA sequence difference between the two sample groups. The age of onset of population subdivision appears to be about 200 thousand years ago. This predates the earliest modern human fossils, suggesting the transformation to modern humans occurred in a subdivided population. The base of the PDHA1 gene tree is relatively ancient, with an estimated age of 1.86 million… Expand
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  • Medicine, Biology
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2001
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Coalescence analysis indicates that the time to the most recent common ancestor predates the appearance of anatomically modern human forms, and a pattern of nuclear variability can be reconciled with inferences based on mitochondrial DNA. Expand
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