X chromosome aneuploidy in the Alzheimer’s disease brain

  title={X chromosome aneuploidy in the Alzheimer’s disease brain},
  author={Yuri B. Yurov and Svetlana G. Vorsanova and Thomas Liehr and Alexei D. Kolotii and Ivan Y. Iourov},
  booktitle={Molecular Cytogenetics},
Although the link between brain aging and Alzheimer’s disease (AD) is a matter of debate, processes hallmarking cellular and tissue senescence have been repeatedly associated with its pathogenesis. Here, we have studied X chromosome aneuploidy (a recognized feature of aged cell populations) in the AD brain. Extended molecular neurocytogenetic analyses of X chromosome aneuploidy in 10 female AD as well as 10 age and sex matched female control postmortem brain samples was performed by multiprobe… CONTINUE READING
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Interphase chromosomes of the human brain: the biological and clinical meaning of neural aneuploidy

  • IY Iourov, SG Vorsanova, YB Yurov
  • Edited by Yurov YB, Vorsanova SG, Iourov IY
  • 2013
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