X-Ray Structure Reveals a New Class and Provides Insight into Evolution of Alkaline Phosphatases

Abstract

The alkaline phosphatase (AP) is a bi-metalloenzyme of potential applications in biotechnology and bioremediation, in which phosphate monoesters are nonspecifically hydrolysed under alkaline conditions to yield inorganic phosphate. The hydrolysis occurs through an enzyme intermediate in which the catalytic residue is phosphorylated. The reaction, which also… (More)
DOI: 10.1371/journal.pone.0022767

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