X-Ray Crystal Structure of the Full Length Human Chitotriosidase (CHIT1) Reveals Features of Its Chitin Binding Domain

Abstract

Chitinases are enzymes that catalyze the hydrolysis of chitin. Human chitotriosidase (CHIT1) is one of the two active human chitinases, involved in the innate immune response and highly expressed in a variety of diseases. CHIT1 is composed of a catalytic domain linked by a hinge to its chitin binding domain (ChBD). This latter domain belongs to the… (More)
DOI: 10.1371/journal.pone.0154190

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@inproceedings{Fadel2016XRayCS, title={X-Ray Crystal Structure of the Full Length Human Chitotriosidase (CHIT1) Reveals Features of Its Chitin Binding Domain}, author={Firas Fadel and Yuguang Zhao and Alexandra Cousido-Siah and Francesc Xavier Ruiz and Andr{\'e} Mitschler and Alberto D Podjarny}, booktitle={PloS one}, year={2016} }