X-Linked G6PD Deficiency Protects Hemizygous Males but Not Heterozygous Females against Severe Malaria


BACKGROUND Glucose-6-phosphate dehydrogenase (G6PD) is important in the control of oxidant stress in erythrocytes, the host cells for Plasmodium falciparum. Mutations in this enzyme produce X-linked deficiency states associated with protection against malaria, notably in Africa where the A- form of G6PD deficiency is widespread. Some reports have proposed… (More)


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