X-LRT: a likelihood approach to estimate genetic risks and test association with X-linked markers using a case-parents design.

@article{Zhang2008XLRTAL,
  title={X-LRT: a likelihood approach to estimate genetic risks and test association with X-linked markers using a case-parents design.},
  author={Li Zhang and E. R. Martin and Ren-Hua Chung and Yi-Ju Li and Richard W. Morris},
  journal={Genetic epidemiology},
  year={2008},
  volume={32 4},
  pages={
          370-80
        }
}
Recently, there has been interest in family-based tests of association to identify X-chromosome genes. However, none of the approaches allow for estimation of genetic risks. We propose a likelihood approach to estimate disease-related marker relative risks and test genotype association using a case-parents design. The test uses nuclear families with a single affected proband and allows additional siblings and missing parental genotypes. Extension to a haplotype test is based on assumptions of… CONTINUE READING

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