X Chromosome Inactivation and Xist Evolution in a Rodent Lacking LINE-1 Activity

@inproceedings{Cantrell2009XCI,
  title={X Chromosome Inactivation and Xist Evolution in a Rodent Lacking LINE-1 Activity},
  author={Michael A. Cantrell and Bryan C. Carstens and Holly A. Wichman},
  booktitle={PloS one},
  year={2009}
}
Dosage compensation in eutherian mammals occurs by inactivation of one X chromosome in females. Silencing of that X chromosome is initiated by Xist, a large non-coding RNA, whose coating of the chromosome extends in cis from the X inactivation center. LINE-1 (L1) retrotransposons have been implicated as possible players for propagation of the Xist signal, but it has remained unclear whether they are essential components. We previously identified a group of South American rodents in which L1… CONTINUE READING
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