X Chromosome Inactivation Is Mediated by Xist RNA Stabilization

  title={X Chromosome Inactivation Is Mediated by Xist RNA Stabilization},
  author={Barbara Panning and Jessica A. Dausman and Rudolf Jaenisch},
Low level Xist expression can be detected from both active X chromosomes (Xa) in female embryonic stem cells prior to X inactivation. After differentiation, Xist is expressed at high levels only from the inactive X chromosome (Xi). Differentiating female cells increase Xist expression from the Xi prior to silencing low level Xist expression from the Xa. The transition from low level to high level expression is regulated by the stabilization of Xist transcripts at the Xi. We suggest that these… CONTINUE READING
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X chromosome inactivation protection assays were carried out using the RPA II kit ( Ambion ) . studied by injection of a single cell into the mouse blastocyst

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