X‐Linked testicular feminization in the mouse as a non‐inducible regulatory mutation of the Jacob‐Monod type
@article{Ohno1970XLinkedTF, title={X‐Linked testicular feminization in the mouse as a non‐inducible regulatory mutation of the Jacob‐Monod type}, author={S. Ohno and M. Lyon}, journal={Clinical Genetics}, year={1970}, volume={1} }
Testosterone and 5 α‐dihydrotestosterone normally induce alcohol dehydrogenase (ADH) production in the mouse kidney. The following results suggest that the X‐linked testicular feminization (T fm) mutation in the mouse is a non‐inducible mutation of a repressive regulatory gene locus. Eleven affected XTfmY mice and 3 XTfm X+ heterozygous females, as well as their normal sibs, were challenged with 10 mg of either testosterone or 5α‐dihydrotestosterone and killed 5 days later. Kidney ADH of normal… CONTINUE READING
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GENETIC REGULATION OF THE ANDROGEN RECEPTOR—A STUDY OF TESTICULAR FEMINIZATION IN THE MOUSE*
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The effect of the mouse X‐linked Testicular feminization mutation on the hypothalamus‐pituitary axis.
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