X‐Linked testicular feminization in the mouse as a non‐inducible regulatory mutation of the Jacob‐Monod type

@article{Ohno1970XLinkedTF,
  title={X‐Linked testicular feminization in the mouse as a non‐inducible regulatory mutation of the Jacob‐Monod type},
  author={S. Ohno and M. Lyon},
  journal={Clinical Genetics},
  year={1970},
  volume={1}
}
Testosterone and 5 α‐dihydrotestosterone normally induce alcohol dehydrogenase (ADH) production in the mouse kidney. The following results suggest that the X‐linked testicular feminization (T fm) mutation in the mouse is a non‐inducible mutation of a repressive regulatory gene locus. Eleven affected XTfmY mice and 3 XTfm X+ heterozygous females, as well as their normal sibs, were challenged with 10 mg of either testosterone or 5α‐dihydrotestosterone and killed 5 days later. Kidney ADH of normal… Expand
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