Wwox deficiency in human cancers : Role in treatment resistance

  • Elsie Olán
  • Published 2017

Abstract

WWOX gene deletions occur in a variety of human cancer types, and reduced Wwox protein expression can be detected early during cancer development. In this study, loss of expression of the fragile site-encoded Wwox protein was found to contribute to radiation and cisplatin resistance of cells, responses that could be associated with cancer recurrence and… (More)

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