Wunen, a Drosophila lipid phosphate phosphatase, is required for septate junction-mediated barrier function.

@article{Ile2012WunenAD,
  title={Wunen, a Drosophila lipid phosphate phosphatase, is required for septate junction-mediated barrier function.},
  author={Kristina Elizabeth Ile and Ratna Tripathy and Valentina Goldfinger and Andrew Renault},
  journal={Development},
  year={2012},
  volume={139 14},
  pages={
          2535-46
        }
}
Lipid phosphate phosphatases (LPPs) are integral membrane enzymes that regulate the levels of bioactive lipids such as sphingosine 1-phosphate and lysophosphatidic acid. The Drosophila LPPs Wunen (Wun) and Wunen-2 (Wun2) have a well-established role in regulating the survival and migration of germ cells. We now show that wun has an essential tissue-autonomous role in development of the trachea: the catalytic activity of Wun is required to maintain septate junction (SJ) paracellular barrier… CONTINUE READING
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