WrbA bridges bacterial flavodoxins and eukaryotic NAD(P)H:quinone oxidoreductases.

  title={WrbA bridges bacterial flavodoxins and eukaryotic NAD(P)H:quinone oxidoreductases.},
  author={Jannette Carey and J{\'i}r{\'i} Brynda and Julie Wolfov{\'a} and Rita Grandori and Tobias Gustavsson and R{\"u}diger H Ettrich and Ivana Kut{\'a} Smatanov{\'a}},
  journal={Protein science : a publication of the Protein Society},
  volume={16 10},
The crystal structure of the flavodoxin-like protein WrbA with oxidized FMN bound reveals a close relationship to mammalian NAD(P)H:quinone oxidoreductase, Nqo1. Structural comparison of WrbA, flavodoxin, and Nqo1 indicates how the twisted open-sheet fold of flavodoxins is elaborated to form multimers that extend catalytic function from one-electron transfer between protein partners using FMN to two-electron reduction of xenobiotics using FAD. The structure suggests a novel physiological role… CONTINUE READING