Wp specific methylation of highly proliferated LCLs.

  title={Wp specific methylation of highly proliferated LCLs.},
  author={Jung-hoon Park and Jae-Pil Jeon and Sung-Mi Shim and Hye-young Nam and Joon-Woo Kim and Bok-ghee Han and Suman Lee},
  journal={Biochemical and biophysical research communications},
  volume={358 2},
The epigenetic regulation of viral genes may be important for the life cycle of EBV. We determined the methylation status of three viral promoters (Wp, Cp, Qp) from EBV B-lymphoblastoid cell lines (LCLs) by pyrosequencing. Our pyrosequencing data showed that the CpG region of Wp was methylated, but the others were not. Interestingly, Wp methylation was increased with proliferation of LCLs. Wp methylation was as high as 74.9% in late-passage LCLs, but 25.6% in early-passage LCLs. From two… CONTINUE READING

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