Wound repair and regeneration

  title={Wound repair and regeneration},
  author={Geoffrey C. Gurtner and Sabine Werner and Yann Barrandon and Michael T. Longaker},
The repair of wounds is one of the most complex biological processes that occur during human life. After an injury, multiple biological pathways immediately become activated and are synchronized to respond. In human adults, the wound repair process commonly leads to a non-functioning mass of fibrotic tissue known as a scar. By contrast, early in gestation, injured fetal tissues can be completely recreated, without fibrosis, in a process resembling regeneration. Some organisms, however, retain… 
Induction of the Fetal Scarless Phenotype in Adult Wounds: Impossible?
This chapter outlines the molecular and cellular processes involved in scarless fetal wound healing and the progress that has been made in recapitulating this process in adult wounds.
Strategies for Optimizing Wound Healing and Reducing Scarring
The repairing of injured skin tissue is a fundamental biological process essential to the continuity of life and consists of inflammation, angiogenesis, and tissue formation and remodeling.
Wound healing and fibrosis: current stem cell therapies
Stem cells are crucial to the innate tissue healing response and, as such, present a possible modality to therapeutically promote regenerative healing while minimizing scaring.
Mechanotransduction in Wound Healing and Fibrosis
A better understanding of the mechanobiology of cells in the skin is essential in the development of efficacious therapeutics to reduce skin disorders, normalize abnormal wound healing, and minimize scar formation.
Introduction to Wound Healing and Tissue Repair
  • S. Eming
  • Biology
    Atlas of Ulcers in Systemic Sclerosis
  • 2018
In most tissues the healing process follows in different organs the principle of sequential phases that overlap in time and space: hemostasis, inflammation, tissue formation, and tissue remodeling.
Tissue engineering in wound repair: the three "R"s--repair, replace, regenerate.
  • C. Theoret
  • Medicine, Biology
    Veterinary surgery : VS
  • 2009
Tissue engineering has emerged as an interdisciplinary field with the aim to regenerate new biological material for replacing diseased or damaged tissues or organs, and the ultimate goal is to rapidly create a construct that effects the complete regeneration of functional skin, including all its layers and appendages.
Cellular and biological factors involved in healing wounds and burns and treatment options in tissue engineering.
The authors focus on the importance of theskin microenvironment, the pathophysiology of various types of burns, mechanisms and factors involved in skin repair and wound healing and regeneration of the skin using tissue engineering approaches.
Matrix control of scarring
This work presents a hypothesis that it is the matrix itself that is a primary driver of scar, rather than being simply the result of other cellular dysregulations.
Wound healing: a paradigm for regeneration.


Fetal wound healing.
The future of wound manipulations may involve the crafting of complex matrices interwoven with a variety of cytokinetic agents, which could result in a healed wound or regenerated tissue that is mechanically and functionally equivalent to adjacent unwounded tissue.
Tissue engineering of replacement skin: the crossroads of biomaterials, wound healing, embryonic development, stem cells and regeneration
The challenge is to identify the factors and cytokines expressed during regeneration and incorporate them to create a smart matrix for use in a skin equivalent, and recent advances in the use of DNA microarray and proteomic technology are likely to aid the identification of such molecules.
Scar-free healing: from embryonic mechanisms to adult therapeutic intervention.
  • M. Ferguson, S. O'Kane
  • Medicine, Biology
    Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 2004
Scar-improving drugs could have widespread benefits and prevent complications in several tissues, e.g. prevention of blindness after scarring due to eye injury, facilitation of neuronal reconnections in the central and peripheral nervous system by the elimination of glial scarring, restitution of normal gut and reproductive function by prevents strictures and adhesions after injury to the gastrointestinal or reproductive systems, and restoration of locomotor function by preventing scarring in tendons and ligaments.
Wound-healing studies in transgenic and knockout mice
This article focuses on the studies in which genetically modified mouse models have helped elucidate the roles that many soluble mediators play during wound repair, encompassing the fibroblast growth factor (FGF) and transforming growth factor-β (TGF-β) families and also data on cytokines and chemokines.
Molecular and Cellular Basis of Regeneration and Tissue Repair
Progress in stem and progenitor cell biology and recognition of the unique properties of such cells may enable intelligent bioengineering design of replacement skin which allows regeneration to occur in vivo.
Inflammatory cells during wound repair: the good, the bad and the ugly.
Regulation of wound healing by growth factors and cytokines.
This review summarizes the results of expression studies that have been performed in rodents, pigs, and humans to localize growth factors and their receptors in skin wounds and reports on genetic studies addressing the functions of endogenous growth factors in the wound repair process.
Parallels between tissue repair and embryo morphogenesis
It is described how almost identical cytoskeletal machinery is used to repair an embryonic epithelial wound as is involved during the morphogenetic episodes of dorsal closure in Drosophila and eyelid fusion in the mouse foetus.
Keratinocyte-fibroblast interactions in wound healing.
This review focuses on the role of keratinocyte-fibroblast interactions in the wound-healing process and the phenotype of fibroblasts from different tissues or body sites becomes better defined, so as to understand their individual contribution in wound healing in more detail and possibly explain different clinical outcomes.
Conserved mechanisms of repair: from damaged single cells to wounds in multicellular tissues
  • K. Woolley, P. Martín
  • Biology
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2000
This review discusses what is known about how the plasma membrane of a single cell and its underlying cortical cytoplasm are repaired following cell damage, and how multicellular wounds to the embryonic and adult skin are also able to heal.