Wound infection prophylaxis with topical ampicillin (Pentrexyl R ) in gastric surgery.

@article{Madsen1971WoundIP,
  title={Wound infection prophylaxis with topical ampicillin (Pentrexyl R ) in gastric surgery.},
  author={P. Madsen and F. Rasmussen and O. Hansen},
  journal={Scandinavian journal of gastroenterology},
  year={1971},
  volume={6 3},
  pages={
          237-40
        }
}
Sequential analysis of a double-blind, fixed dose, controlled clinical trial comprising 64 patients treated by truncal vagotomy and pyloroplasty demonstrated a statistically significant reduction of postoperative wound infections by topical application of ampicillin in the wound. 
Rational use of prophylactic antibiotics in gastrointestinal surgery.
  • R. Condon
  • Medicine
  • The Surgical clinics of North America
  • 1975
This article reviews the literature of antibiotic prophylaxis and records the author’s recommendations regarding this procedure in patients having gastrointestinal tract operations.
Wound infection and topical antibiotics: the surgeon's dilemma.
TLDR
The application of carefully selected topical antibiotics to surgical wounds, particularly those that represent a high risk for the development of wound infection, can be expected to diminish the incidence of this complication in a significant fashion. Expand
The role of topical antibiotics in "high-risk" biliary surgery.
TLDR
It is suggested that topical antibiotics provide effective prophylaxis in biliary tract surgery and that broad-spectrum systemic antibiotic therapy is of no additional benefit. Expand
Polyglycolic acid, silk, and topical ampicillin. Their use in hernia repair and cholecystectomy.
TLDR
Wound infection was significantly more frequent in patients with postoperative seromas or hematomas, and the effect of ampicillin could be demonstrated, nor was any difference between polyglycolic acid and silk sutures shown. Expand
A controlled trial to compare systemic and intra‐incisional cefuroxime prophylaxis in high risk gastric surgery
TLDR
There was a poor correlation between the individual species isolated from the gastric aspirate and the organisms responsible for postoperative infection in the control group, but there was a good correlation between fasting gastric pH and the risk of sepsis in the controls. Expand
Intra-operative wound irrigation to reduce surgical site infections after abdominal surgery: a systematic review and meta-analysis
TLDR
Results suggest that IOWI before skin closure represents a pragmatic and economical approach to reduce postoperative SSI after abdominal surgery and that antibiotic solutions seem to be more effective than PVP-I solutions or simple saline, and it might be worth to re-evaluate their use for specific indications. Expand
Prediction of wound sepsis following gastric operations
TLDR
The mean total viable bacterial counts in these groups were as follows: volunteers 0, duodenal ulcer 3.8 × 101, gastric ulcer 6.95 × 104, carcinoma 1.9 × 107 organisms/ml. Expand
Measurement of gastric juice pH should not be used for selecting high risk patients requiring antibiotic prophylaxis in gastric surgery.
TLDR
The results imply that all patients undergoing gastric operation should receive antimicrobial prophylaxis and that cefuroxime remains a suitable agent for these patients. Expand
Prevention of sepsis in gastroesophageal surgery
TLDR
Systemic antimicrobial prophylaxis with a broad-spectrum cephalosporin or penicillin is advised for all patients receiving cimetidine before operation, for patients requiring gastric resection or revision gastric operations, and for any others in whom the preoperative gastric pH is 4.0 or more. Expand

References

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Topical ampicillin in the appendicectomy wound: Report of double-blind trial
TLDR
One hundred and thirty unselected patients undergoing appendicectomy were treated with topical ampicillin powder or topical placebo powder (lactose) before closing the wound, and the postoperative wound infection rates were significant, not influenced by the degree of inflammation in the appendix. Expand
Topical ampicillin and wound infection in colon surgery.
TLDR
It is reasonable to assume that most wound infections after operations on the large bowel are initiated in the operating theatre, and that the source of the organisms is the bowel. Expand
The effective period of preventive antibiotic action in experimental incisions and dermal lesions.
There is a definite short period when the developing staphylococcal dermal or incisional infection may be suppressed by antibiotics. This effective period begins the moment bacteria gain access toExpand