Wound healing: the role of gap junctional communication in rat granulation tissue maturation.

@article{Moyer2002WoundHT,
  title={Wound healing: the role of gap junctional communication in rat granulation tissue maturation.},
  author={Kurtis E. Moyer and Alan C. Davis and Gregory C Saggers and Donald Roy Mackay and Heinrich Ehrlich},
  journal={Experimental and molecular pathology},
  year={2002},
  volume={72 1},
  pages={
          10-6
        }
}
Granulation tissue maturation is dependent upon the orientation of collagen fibers and cell differentiation. Gap junctions are intercellular membrane gated channels that facilitate direct communication between cells known as gap junctional intercellular communication (GJIC). The hypothesis is that GJIC modulates the maturation of granulation tissue during wound repair. In vitro, GJIC optimizes fibroblast-populated collagen lattice contraction and influences cell morphology. It is reported that… CONTINUE READING
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