Wound healing: from embryos to adults and back again

@article{Tredget2009WoundHF,
  title={Wound healing: from embryos to adults and back again},
  author={Edward E. Tredget and Jie Ding},
  journal={The Lancet},
  year={2009},
  volume={373},
  pages={1226-1228}
}
The Controversial Role of Fibrosis in Autosomal Dominant Polycystic Kidney Disease
TLDR
The stages of fibrosis progression in ADPKD, and how these compare with other common kidney diseases are discussed, and the role of the ‘chronic hypoxia hypothesis’, persistent inflammation, Transforming Growth Factor beta, Janus Kinase/Signal Transducers and Activators of Transcription and microRNAs are examined.
Transplanting Human Skin Grafts onto Nude Mice to Model Skin Scars.
TLDR
In this chapter, the detailed procedures to create the ideal dermal fibrotic mouse model are introduced and the advantages of lower cost, easier manipulation, and shorter research period are introduced.
A Novel Nude Mouse Model of Hypertrophic Scarring Using Scratched Full Thickness Human Skin Grafts.
TLDR
Deep dermal injury in human skin retains its profibrotic nature after transplantation, affording a novel model for the assessment of therapies for the treatment of human fibroproliferative disorders of the skin.
The therapeutic potential of a C‐X‐C chemokine receptor type 4 (CXCR‐4) antagonist on hypertrophic scarring in vivo
  • Jie Ding, Zengshuan Ma, E. Tredget
  • Biology, Medicine
    Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
  • 2014
TLDR
The inhibitory effect of CXCR4 antagonist CTCE‐9908 on dermal fibrosis was determined in vivo using a human HTS‐like nude mouse model, and these findings support the potential therapeutic value of C X CR4 antagonist in dermal Fibrosis and possibly other fibroproliferative disorders.
Functional characterization of the PlGF-2 heparin-binding domain
TLDR
The findings indicate that the heparinbinding domain of PlGF-2 stimulates endothelial cell functions in vitro and promotes angiogenesis in vivo and is a target of the serine protease plasmin.
Interplay between vascular endothelial growth factor-A and extracellular matrix in angiogenesis: molecular and cellular mechanisms
TLDR
This study optimized wound angiogenesis in non-healing wounds in response to recombinant VEGF-A165 by improving bioavailability and potency of the growth factor and indicates that the immobilized proteins show different potential in the induction of cellular responses.
Repairing Extracellular Aging and Glycation
TLDR
It is anticipated that repair and rejuvenation of a wide range of extracellular aging and damage may be achieved by stimulating fibroblast-lineage cells to more rapidly turn over and regenerate theextracellular matrix.

References

SHOWING 1-10 OF 16 REFERENCES
Pathophysiology and management of the burn scar.
Regulatory T cells as targets for immunotherapy of autoimmunity and inflammation.
TLDR
Current concepts on different cell types, components and some novel surface receptors expressed by Treg cells, namely Neuropilin-1, CD83 and G protein-coupled receptor 83 which might represent promising targets for the modulation of Treg cell function in human disease are discussed.
Cellular and molecular pathology of HTS: basis for treatment
  • A. Armour, P. Scott, E. Tredget
  • Biology, Medicine
    Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
  • 2007
TLDR
The systemic response to injury appears to influence the local healing process whereby increases in Th2 and possibly Th3 cytokines such as IL‐2, IL‐4 and IL‐10 and TGF‐β are present in the circulating lymphocytes in these fibrotic conditions.
Scarring Occurs at a Critical Depth of Skin Injury: Precise Measurement in a Graduated Dermal Scratch in Human Volunteers
TLDR
The dermal scratch provides a well-tolerated, standardized, and reproducible wound model for investigating the healing response to dermal injury of different depths, and indicates that there is a threshold depth of Dermal injury at which scarring develops.
TGF‐β–induced fibrosis and SMAD signaling: oligo decoys as natural therapeutics for inhibition of tissue fibrosis and scarring
  • K. Cutroneo
  • Biology, Chemistry
    Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
  • 2007
TLDR
The significance of the proposed studies is that these novel natural antifibrotics will mimic the effect of glucocorticoids on collagen synthesis during fibrogenesis without the unwanted side effects of these steroids.
The Role of PPARs in Lung Fibrosis
TLDR
The clinical availability of potent and selective PPARα and PPARγ agonists should facilitate rapid development of successful treatment strategies based on current and ongoing research.
Polarized Th2 cytokine production in patients with hypertrophic scar following thermal injury.
Following thermal injury, hypertrophic scar (HSc) is a frequent and severe form of fibrosis of the skin, which limits movement and compromises the cosmetic appearance and function of the skin.
Visual Analogue Scale Scoring and Ranking: A Suitable and Sensitive Method for Assessing Scar Quality?
TLDR
The authors have shown the visual analogue scale scar scoring and scar ranking methods to be consistent, reliable, valid, and feasible for scar assessment.
...
1
2
...