Wound healing: from embryos to adults and back again

@article{Tredget2009WoundHF,
  title={Wound healing: from embryos to adults and back again},
  author={Edward E. Tredget and Jie Ding},
  journal={The Lancet},
  year={2009},
  volume={373},
  pages={1226-1228}
}
The Controversial Role of Fibrosis in Autosomal Dominant Polycystic Kidney Disease
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The stages of fibrosis progression in ADPKD, and how these compare with other common kidney diseases are discussed, and the role of the ‘chronic hypoxia hypothesis’, persistent inflammation, Transforming Growth Factor beta, Janus Kinase/Signal Transducers and Activators of Transcription and microRNAs are examined.
Transplanting Human Skin Grafts onto Nude Mice to Model Skin Scars.
TLDR
In this chapter, the detailed procedures to create the ideal dermal fibrotic mouse model are introduced and the advantages of lower cost, easier manipulation, and shorter research period are introduced.
A Novel Nude Mouse Model of Hypertrophic Scarring Using Scratched Full Thickness Human Skin Grafts.
TLDR
Deep dermal injury in human skin retains its profibrotic nature after transplantation, affording a novel model for the assessment of therapies for the treatment of human fibroproliferative disorders of the skin.
The therapeutic potential of a C‐X‐C chemokine receptor type 4 (CXCR‐4) antagonist on hypertrophic scarring in vivo
  • Jie Ding, Zengshuan Ma, E. Tredget
  • Biology, Medicine
    Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
  • 2014
TLDR
The inhibitory effect of CXCR4 antagonist CTCE‐9908 on dermal fibrosis was determined in vivo using a human HTS‐like nude mouse model, and these findings support the potential therapeutic value of C X CR4 antagonist in dermal Fibrosis and possibly other fibroproliferative disorders.
Interplay between vascular endothelial growth factor-A and extracellular matrix in angiogenesis: molecular and cellular mechanisms
TLDR
This study optimized wound angiogenesis in non-healing wounds in response to recombinant VEGF-A165 by improving bioavailability and potency of the growth factor and indicates that the immobilized proteins show different potential in the induction of cellular responses.
Functional characterization of the PlGF-2 heparin-binding domain
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The findings indicate that the heparinbinding domain of PlGF-2 stimulates endothelial cell functions in vitro and promotes angiogenesis in vivo and is a target of the serine protease plasmin.
Repairing Extracellular Aging and Glycation
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It is anticipated that repair and rejuvenation of a wide range of extracellular aging and damage may be achieved by stimulating fibroblast-lineage cells to more rapidly turn over and regenerate theextracellular matrix.

References

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