Wound contraction is significantly reduced by the use of microcarriers to deliver keratinocytes and fibroblasts in an in vivo pig model of wound repair and regeneration.

@article{Eldardiri2012WoundCI,
  title={Wound contraction is significantly reduced by the use of microcarriers to deliver keratinocytes and fibroblasts in an in vivo pig model of wound repair and regeneration.},
  author={Mohamed Eldardiri and Y H Martin and Judy Roxburgh and Diana J Lawrence-Watt and Justin R. Sharpe},
  journal={Tissue engineering. Part A},
  year={2012},
  volume={18 5-6},
  pages={587-97}
}
In full-thickness injuries caused by extensive burns or penetrating traumatic injuries, the natural epidermal stem cell niche is destroyed, and wound healing occurs through migration of cells from the wound edges and wound contraction. This can lead to significant contracture formation, especially in large full-thickness injuries, causing lack of mobility and pain. Contraction is reduced when wounds are treated using split-thickness skin grafts (STSG) or dermal substitutes, particularly in… CONTINUE READING
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Skin stem cells: rising to the surface

The Journal of cell biology • 2008

Effect of artificial dermal substitute, cultured keratinocytes and split thickness skin graft on wound contraction.

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