Would cyclosporin A be beneficial to mitigate drug-induced toxic epidermal necrolysis?

@article{Paquet1999WouldCA,
  title={Would cyclosporin A be beneficial to mitigate drug-induced toxic epidermal necrolysis?},
  author={Philippe Paquet and G E Pi{\'e}rard},
  journal={Dermatology},
  year={1999},
  volume={198 2},
  pages={198-202}
}
Drug-induced toxic epidermal necrolysis (TEN) is a rare life-threatening disease whose mortality remains high. The treatment of the disease is badly settled. Several kinds of drugs have been tested, including systemic corticosteroids, cyclophosphamide, pentoxifylline and thalidomide, but without any clear-cut outcome. Cyclosporin A (CsA) has many inhibitory effects on the main cell populations involved in TEN (T lymphocytes, macrophages and keratinocytes). CsA could also act on tumor necrosis… CONTINUE READING

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